Towards Synthesis of Atropodiastereomeric Indolostilbenes Hybrids: A New Class of Oligostilbenoids

The conceptually construction of axially chiral indolostilbenesi.eN-(2-{(E)-2-[2'-(1-Acetyl-1H-indol-2-yl)-3'chloro4,4',6,6'-tetramethoxy[1,1'-biphenyl]-2yl]ethenyl}phenyl)acetamide and N-(2-{(E)-2-[2'-(1-Acetyl-1H-indol-2-yl)-3'-chloro-2,4',6,6'tetramethoxy[1,1'-biphenyl]-4-yl]ethenyl}phenyl) acetamide are described in this paper. These structure, were obtained by the tactical combination of palladium-catalyzed coupling which produced 10acetamido-3,5-dimethoxystilbene, follow by FeCl3-induced oxidative cyclization/dimerisation. All structures were unambiguously confirmed by 1D (H, C) and 2D NMR experiment, (COSY, HMQC, HMBC) and mass spectrometry. Keywords—Indolostilbene, FeCl3-oxidative cyclization, Oligostilbenooids, Oxidative cyclization/dimerization.